Sebastian Schmon

Sebastian M. Schmon

Machine Learning Researcher.

Welcome to my webpage! I am a machine learning researcher, statistician, and professional curious person. Currently, I am working on machine learning for biology and I am excited to be part of the team at Latent Labs, where I'm working on developing frontier models for biologics.

Previously, I had the opportunity to contribute to Altos Lab and their mission of transforming medicine through cellular rejuvenation programming, worked as a Research Scientist at Improbable, where I gained valuable experience applying my skills to real-world problems. During my time at Improbable, I also served as an Assistant Professor in Statistics at Durham University, where I enjoyed contributing to the academic community and mentoring the next generation of statisticians and machine learning practitioners. My research interests lie at the intersection of statistics, machine learning, and probability theory, with a particular focus on applications in the sciences. I'm also intrigued by the philosophical aspects of science and enjoy digging into the foundations when the opportunity arises. Recently, I've been working on projects involving generative AI, including large language models, embeddings, and diffusion models. I obtained my DPhil (the Oxford equivalent of a PhD) from the Department of Statistics at the University of Oxford. Below, you'll find a list of my publications, highlighting my contributions to the field.

News

  • Two of my papers have been accepted to the Workshop on the Philosophy of Machine Learning (PhilML) at ICML 2026.

    Reality and Practice: A Relational Reading of the Platonic Representation Hypothesis

    I revisit the Platonic Representation Hypothesis — the claim that large models trained for different objectives converge on a shared statistical model of reality. I accept the empirical convergence but argue the Platonic framing is not forced by the mathematics, and offer a Wittgensteinian alternative: categories are useful compressions linked by family resemblance, and the convergent geometry reflects convergence toward a relational system of use, shaped by human practice under physical constraints. Read on OpenReview.

    Measuring the Ruler: Reading Benchmark Saturation as Evidence

    I argue that the inference from a benchmark score to a capability claim is conditional on the system being evaluated: a benchmark supports a claim only once the benchmark–system pair has been validated. On this view, benchmark saturation is not merely a sign that harder tests are needed — it is evidence about the validity relation itself. Illustrated on MMLU, GSM8K, and HumanEval, the paper proposes a short Validity Transfer Report that benchmark papers can use to make these assumptions explicit. Read on OpenReview.

  • I'm serving as an Area Chair for NeurIPS 2026.

  • We've launched Latent-Y at Latent Labs, the first lab-validated AI agent for drug design, which I lead. Powered by Latent-X2, it autonomously designs antibodies and therapeutic peptides from natural-language prompts — compressing weeks of expert work into hours.

  • Our team at Latent Labs as published a preprint for our new all-atom protein design model Latent-X, where we demonstrate lab-validated state-of-the-art performance for the de-novo design of cyclic peptides and minibinders! Also check out the platform.

All news →

Selected publications

  • Latent-Y: A Lab-Validated Autonomous Agent for De Novo Drug Design
    Sebastian M. Schmon, Daniella Pretorius, Simon Mathis, Rebecca Bartke-Croughan, Aishaini Puvanendran, James Vuckovic, Henry Kenlay, Mária Vlachynská, Alex Bridgland, Ivan Grishin, Sven Over, David Li, Bridget Li, Jonathan Crabbé, Agrin Hilmkil, Alexander W. R. Nelson, David Yuan, Annette Obika, Simon A. A. Kohl · arXiv preprint arXiv:2603.29727 · 2026
  • Drug-like antibodies with low immunogenicity in human panels designed with Latent-X2
    Henry Kenlay, Daniella Pretorius, Jonathan Crabbé, Alex Bridgland, Sebastian M. Schmon, Agrin Hilmkil, James Vuckovic, Simon Mathis, Tomas Matteson, Rebecca Bartke-Croughan, Amir Motmaen, Robin Rombach, Mária Vlachynská, Alexander W. R. Nelson, David Yuan, Annette Obika, Simon A. A. Kohl · arXiv preprint arXiv:2512.20263 · 2025
  • Latent-X: An Atom-level Frontier Model for De Novo Protein Binder Design
    Alex Bridgland, Jonathan Crabbé, Henry Kenlay, Daniella Pretorius, Sebastian M. Schmon, Agrin Hilmkil, Rebecca Bartke-Croughan, Robin Rombach, Michael Flashman, Tomas Matteson, Simon Mathis, Alexander W. R. Nelson, David Yuan, Annette Obika, Simon A. A. Kohl · arXiv preprint arXiv:2507.19375 · 2025
  • Approximate Bayesian Computation with Path Signatures
    Joel Dyer, Patrick Cannon, Sebastian M Schmon · The 40th Conference on Uncertainty in Artificial Intelligence, Spotlight, Best Paper Award · 2024
  • PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis
    Yan Wu, Esther Wershof, Sebastian M Schmon, Marcel Nassar, Blazej Osinski, Ridvan Eksi, Kun Zhang, Thore Graepel · arXiv preprint arXiv:2408.10609 · 2024
  • AnoDDPM: Anomaly detection with denoising diffusion probabilistic models using simplex noise
    Julian Wyatt, Adam Leach, Sebastian Schmon, Chris G Willcocks · Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2022
  • Denoising diffusion probabilistic models on SO(3) for rotational alignment
    Adam Leach, Sebastian Schmon, Matteo T Degiacomi, Chris G Willcocks · ICLR 2022 Workshop on Geometrical and Topological Representation Learning · 2022
  • Learning Multimodal VAEs through Mutual Supervision
    Tom Joy, Yuge Shi, Philip Torr, Tom Rainforth, Sebastian Schmon, Siddharth N · International Conference on Learning Representations · 2022
  • Robust neural posterior estimation and statistical model criticism
    Daniel Ward, Patrick Cannon, Mark Beaumont, Matteo Fasiolo, Sebastian Schmon · Advances in Neural Information Processing Systems · 2022
  • Optimal scaling of random walk Metropolis algorithms using Bayesian large-sample asymptotics
    Sebastian Schmon, Philippe Gagnon · Statistics and Computing · 2022
  • Amortised likelihood-free inference for expensive time-series simulators with signatured ratio estimation
    Joel Dyer, Patrick W Cannon, Sebastian Schmon · International Conference on Artificial Intelligence and Statistics · 2022
  • Capturing Label Characteristics in VAEs
    Tom Joy, Sebastian Schmon, Philip Torr, Siddharth N, Tom Rainforth · International Conference on Learning Representations · 2021
  • Large-sample asymptotics of the pseudo-marginal method
    Sebastian Schmon, George Deligiannidis, Arnaud Doucet, Michael K Pitt · Biometrika · 2021