Sebastian Schmon

Sebastian M. Schmon

Machine Learning Researcher.

Welcome to my webpage! I am a machine learning researcher, statistician, and professional curious person. Currently, I am working on machine learning for biology and I am excited to be part of the team at Latent Labs, where I'm working on developing frontier models for biologics.

Previously, I had the opportunity to contribute to Altos Lab and their mission of transforming medicine through cellular rejuvenation programming, worked as a Research Scientist at Improbable, where I gained valuable experience applying my skills to real-world problems. During my time at Improbable, I also served as an Assistant Professor in Statistics at Durham University, where I enjoyed contributing to the academic community and mentoring the next generation of statisticians and machine learning practitioners. My research interests lie at the intersection of statistics, machine learning, and probability theory, with a particular focus on applications in the sciences. I'm also intrigued by the philosophical aspects of science and enjoy digging into the foundations when the opportunity arises. Recently, I've been working on projects involving generative AI, including large language models, embeddings, and diffusion models. I obtained my DPhil (the Oxford equivalent of a PhD) from the Department of Statistics at the University of Oxford. Below, you'll find a list of my publications, highlighting my contributions to the field.

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Selected publications

  • Drug-like antibodies with low immunogenicity in human panels designed with Latent-X2
    Latent Labs team, Schmon, Sebastian · arXiv preprint arXiv:2512.20263 · 2025
  • Latent-X: An Atom-level Frontier Model for De Novo Protein Binder Design
    Latent Labs team, Schmon, Sebastian · arXiv preprint arXiv:2507.19375 · 2025
  • Approximate Bayesian Computation with Path Signatures
    Joel Dyer, Patrick Cannon, Sebastian M Schmon · The 40th Conference on Uncertainty in Artificial Intelligence, Spotlight, Best Paper Award · 2024
  • PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis
    Wu, Yan, Wershof, Esther, Schmon, Sebastian M, Nassar, Marcel, Osinski, Blazej, Eksi, Ridvan, Zhang, Kun, Graepel, Thore · arXiv preprint arXiv:2408.10609 · 2024
  • Anoddpm: Anomaly detection with denoising diffusion probabilistic models using simplex noise
    Wyatt, Julian, Leach, Adam, Schmon, Sebastian, Willcocks, Chris G · Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2022
  • Denoising diffusion probabilistic models on so (3) for rotational alignment
    Leach, Adam, Schmon, Sebastian, Degiacomi, Matteo T, Willcocks, Chris G · ICLR 2022 Workshop on Geometrical and Topological Representation Learning · 2022
  • Learning Multimodal VAEs through Mutual Supervision
    Tom Joy, Yuge Shi, Philip Torr, Tom Rainforth, Sebastian Schmon, Siddharth N · International Conference on Learning Representations · 2022
  • Robust neural posterior estimation and statistical model criticism
    Ward, Daniel, Cannon, Patrick, Beaumont, Mark, Fasiolo, Matteo, Schmon, Sebastian · Advances in Neural Information Processing Systems · 2022
  • Optimal scaling of random walk Metropolis algorithms using Bayesian large-sample asymptotics
    Schmon, Sebastian, Gagnon, Philippe · Statistics and Computing · 2022
  • Amortised likelihood-free inference for expensive time-series simulators with signatured ratio estimation
    Dyer, Joel, Cannon, Patrick W, Schmon, Sebastian · International Conference on Artificial Intelligence and Statistics · 2022
  • Capturing Label Characteristics in VAEs
    Tom Joy, Sebastian Schmon, Philip Torr, Siddharth N, Tom Rainforth · International Conference on Learning Representations · 2021
  • Large-sample asymptotics of the pseudo-marginal method
    Schmon, Sebastian, Deligiannidis, George, Doucet, Arnaud, Pitt, Michael K · Biometrika · 2021